But there is a precedent, obviously, with influenza virus vaccines, not to do that," Moss said. "So, the influenza vaccine each year doesn't have to go through a large Phase 3 trial." That's because the vaccine technology stays the same, and the only change is the flu virus itself that the vaccine targets to elicit immunity to a specific flu virus strain that's circulating. Moss said that's what he expects could happen with modified coronavirus vaccines. Get Health's weekly newsletter Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the Health team. "At this time, available information suggests that the FDA-authorized vaccines remain effective in protecting the American public against currently circulating strains of SARS-CoV-2. However, if there is an emergence of SARS-CoV-2 variant(s) in the U.S. that are moderately or fully resistant to the antibody response elicited by the current generation of COVID-19 vaccines, it may be necessary to tailor the vaccines to the variant(s)," an FDA spokesperson told on Thursday. The FDA updated its guidance for vaccine developers in February, noting that manufacturers should "generate the data to support authorization" of a modified vaccine. "Further discussions will be necessary to decide whether, in the future, modified COVID-19 vaccines may be authorized without the need for clinical studies," according to the guidance.
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